期刊
ACS CHEMICAL NEUROSCIENCE
卷 6, 期 7, 页码 1055-1070出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.5b00021
关键词
Serotonin; dopamine; development; interaction; clinical disorders; behavior; pharmacotherapeutics; midbrain; hindbrain
资金
- NIH [R01 DA034022, R21 DA036056, R21 DA023643]
- GVR Khodadad Research Award
The complex integration of neurotransmitter signals in the nervous system contributes to the shaping of behavioral and emotional constitutions throughout development. Imbalance among these signals may result in pathological behaviors and psychiatric illnesses. Therefore, a better understanding of the interplay between neurotransmitter systems holds potential to facilitate therapeutic development. Of particular clinical interest are the dopaminergic and serotonergic systems, as both modulate a broad array of behaviors and emotions and have been implicated in a wide range of affective disorders. Here we review evidence speaking to an interaction between the dopaminergic and serotonergic neuronal systems across development. We highlight data stemming from developmental, functional, and clinical studies, reflecting the importance of this transmonoaminergic interplay.
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