相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The role of ligand efficiency metrics in drug discovery
Andrew L. Hopkins et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Using a Fragment-Based Approach To Target Protein-Protein Interactions
Duncan E. Scott et al.
CHEMBIOCHEM (2013)
Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development
Qingjie Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew J. Souers et al.
NATURE MEDICINE (2013)
Targeting protein-protein interactions as an anticancer strategy
Andrei A. Ivanov et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein-Protein Interaction Inhibitor
David C. Fry et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
Qi Sun et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Fragment-Based Approaches in Drug Discovery and Chemical Biology
Duncan E. Scott et al.
BIOCHEMISTRY (2012)
Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface
Inge Van Molle et al.
CHEMISTRY & BIOLOGY (2012)
Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
John A. Flygare et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
Isabelle Ray-Coquard et al.
LANCET ONCOLOGY (2012)
Linking the Cellular Functions of BRCA Genes to Cancer Pathogenesis and Treatment
Ashok R. Venkitaraman
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)
Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database
Alicia P. Higueruelo et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2009)
Predicting druggable binding sites at the protein-protein interface
Jonathan C. Fuller et al.
DRUG DISCOVERY TODAY (2009)
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
James A. Wells et al.
NATURE (2007)
The influence of drug-like concepts on decision-making in medicinal chemistry
Paul D. Leeson et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: The same but for different reasons
Christof Gerlach et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design
Desiree H. H. Tsao et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis
AM Petros et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange
Mahmud K. K. Shivji et al.
NUCLEIC ACIDS RESEARCH (2006)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Protein-protein interactions and cancer: small molecules going in for the kill
M Arkin
CURRENT OPINION IN CHEMICAL BIOLOGY (2005)
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
MR Arkin et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
L Pellegrini et al.
NATURE (2002)
分享论文
