期刊
CHEMMEDCHEM
卷 7, 期 9, 页码 1527-1536出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201200155
关键词
antiviral agents; drug design; influenza; inhibitors; neuraminidase
资金
- National Basic Research Program of China [2009CB940903, 2012CB518000]
- National Natural Science Foundation of China [20721003, 81025017]
- National S&T Major Projects [2012ZX09103-101-072]
The recent emergence of the highly pathogenic H5N1 subtype of avian influenza virus (AIV) and of the new type of human influenza A (H1N1) have emphasized the need for the development of effective anti-influenza drugs. Presently, neuraminidase (NA) inhibitors are widely used in the treatment and prophylaxis of human influenza virus infection, and tremendous efforts have been made to develop more potent NA inhibitors to combat resistance and new influenza viruses. In this review, we discuss the structural characteristics of NA catalytic domains and the recent developments of new NA inhibitors using structure-based drug design strategies. These drugs include analogues of zanamivir, analogues of oseltamivir, analogues of peramivir, and analogues of aromatic carboxylic acid and present promising options for therapeutics or leads for further development of NA inhibitors that may be useful in the event of a future influenza pandemic.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据