相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The Differential Effect of Intrathecal Nav1.8 Blockers on the Induction and Maintenance of Capsaicin- and Peripheral Ischemia-Induced Mechanical Allodynia and Thermal Hyperalgesia
Ji-Young Moon et al.
ANESTHESIA AND ANALGESIA (2012)
Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists
Hanh Nho Nguyen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Nav1.7 antagonists
Nagasree Chakka et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR
Howard Bregman et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Binding Modes of μ-Conotoxin to the Bacterial Sodium Channel (NavAb)
Rong Chen et al.
BIOPHYSICAL JOURNAL (2012)
Pain Disorders and Erythromelalgia Caused by Voltage-Gated Sodium Channel Mutations
Ron Dabby
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2012)
Sodium Channel Blockers as Therapeutic Target for Treating Epilepsy: Recent Updates
Valentina Zuliani et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Biophysical characterization of M1476I, a sodium channel founder mutation associated with cold-induced myotonia in French Canadians
Juan Zhao et al.
JOURNAL OF PHYSIOLOGY-LONDON (2012)
Tetrodotoxin (TTX) as a Therapeutic Agent for Pain
Francisco Rafael Nieto et al.
MARINE DRUGS (2012)
China must provide education on HIV
Jian Zhang et al.
NATURE (2012)
Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine
Ryoko Hirakawa et al.
NEUROPHARMACOLOGY (2012)
Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker
Yigal Paul Goldberg et al.
PAIN (2012)
Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads
Julie K. Klint et al.
TOXICON (2012)
Severe case and literature review of primary erythromelalgia: Novel SCN9A gene mutation
Nedaa Skeik et al.
VASCULAR MEDICINE (2012)
Architecture and Pore Block of Eukaryotic Voltage-Gated Sodium Channels in View of NavAb Bacterial Sodium Channel Structure
Denis B. Tikhonov et al.
MOLECULAR PHARMACOLOGY (2012)
Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Na(v)1.5 channels
Hai Huang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)
Validation of a Patch Clamp Screening Protocol That Simultaneously Measures Compound Activity in Multiple States of the Voltage-Gated Sodium Channel Nav1.2
Yi Liu et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2011)
Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship
Istvan Macsari et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain
Sultan Chowdhury et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Deletion mutation of sodium channel NaV1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability
Xiaoyang Cheng et al.
BRAIN (2011)
The 'overly-sensitive' heart: sodium channel block and QRS interval prolongation
Gary A. Gintant et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
On the relationship between block of the cardiac Na+ channel and drug-induced prolongation of the QRS complex
A. R. Harmer et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Targeting Voltage-Gated Sodium Channels for Treating Neuropathic and Inflammatory Pain
Charles J. Cohen
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2011)
Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain
Roland Staud et al.
EUROPEAN JOURNAL OF PAIN (2011)
Elucidation of the Molecular Basis of Selective Recognition Uncovers the Interaction Site for the Core Domain of Scorpion α-Toxins on Sodium Channels
Maya Gur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+ Channel Voltage Sensors in Domains II and IV
Yucheng Xiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Identification of New Batrachotoxin-sensing Residues in Segment IIIS6 of the Sodium Channel
Yuzhe Du et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels
Joel Z. Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis
Fenfen Wu et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors
Frank Bosmans et al.
JOURNAL OF GENERAL PHYSIOLOGY (2011)
Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain
Howard Bregman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Resurgent currents turn painfully exciting
Angelika Lampert
JOURNAL OF PHYSIOLOGY-LONDON (2011)
Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain?
Wei Wang et al.
MOLECULAR PAIN (2011)
Inhibition of Navβ4 Peptide-Mediated Resurgent Sodium Currents in Nav1.7 Channels by Carbamazepine, Riluzole, and Anandamide
Jonathan W. Theile et al.
MOLECULAR PHARMACOLOGY (2011)
Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia
Charles B. Berde et al.
MARINE DRUGS (2011)
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia
Jan Weiss et al.
NATURE (2011)
The crystal structure of a voltage-gated sodium channel
Jian Payandeh et al.
NATURE (2011)
Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons
Jin-Sung Choi et al.
NATURE REVIEWS NEUROLOGY (2011)
Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons
Nicholas J. Hargus et al.
NEUROBIOLOGY OF DISEASE (2011)
Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels
Enrico Leipold et al.
NEUROPHARMACOLOGY (2011)
A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain
Michael E. Hildebrand et al.
PAIN (2011)
The Roles of Sodium Channels in Nociception: Implications for Mechanisms of Neuropathic Pain
Min Liu et al.
PAIN MEDICINE (2011)
Blockade of Persistent Sodium Currents Contributes to the Riluzole-Induced Inhibition of Spontaneous Activity and Oscillations in Injured DRG Neurons
Rou-Gang Xie et al.
PLOS ONE (2011)
Nav1.9 Channel Contributes to Mechanical and Heat Pain Hypersensitivity Induced by Subacute and Chronic Inflammation
Stephane Lolignier et al.
PLOS ONE (2011)
Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome
A. S. Amin et al.
Netherlands Heart Journal (2011)
Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes
Jonathan W. Theile et al.
FRONTIERS IN PHARMACOLOGY (2011)
Neurotoxins and their binding areas on voltage-gated sodium channels
Marijke Stevens et al.
FRONTIERS IN PHARMACOLOGY (2011)
Familial pain syndromes from mutations of the Na(v)1.7 sodium channel
Tanya Z. Fischer et al.
YEAR IN NEUROLOGY 2 (2010)
Sodium Channels in Normal and Pathological Pain
Sulayman D. Dib-Hajj et al.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 33 (2010)
Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice
Sandra Leo et al.
BEHAVIOURAL BRAIN RESEARCH (2010)
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain
Marc J. C. Scanio et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives
Michael E. Kort et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers
Sriram Tyagarajan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Substituted biaryl pyrazoles as sodium channel blockers
Sriram Tyagarajan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain
Sriram Tyagarajan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits
Zhengyu Cao et al.
BMC NEUROSCIENCE (2010)
F 15845, a new blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery
A. Bocquet et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias
C. Pignier et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Ranolazine selectively blocks persistent current evoked by epilepsy-associated NaV1.1 mutations
Kristopher M. Kahlig et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Sodium Channel (Dys)Function and Cardiac Arrhythmias
Carol Ann Remme et al.
CARDIOVASCULAR THERAPEUTICS (2010)
Riluzole, Neuroprotection and Amyotrophic Lateral Sclerosis
B. C. Cheah et al.
CURRENT MEDICINAL CHEMISTRY (2010)
Genetics of Brugada syndrome
Oscar Campuzano et al.
CURRENT OPINION IN CARDIOLOGY (2010)
A Nonsense Mutation in the SCN9A Gene in Congenital Insensitivity to Pain
Mazen Kurban et al.
DERMATOLOGY (2010)
Sodium channel SCN1A and epilepsy: Mutations and mechanisms
Andrew Escayg et al.
EPILEPSIA (2010)
Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites
Andreas Leffler et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Targeting voltage-gated sodium channels for pain therapy
Jeffrey J. Clare
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
Lacosamide for pain
Gary McCleane
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
Isoform-selective voltage-gated Na+ channel modulators as next-generation analgesics
Steve England et al.
FUTURE MEDICINAL CHEMISTRY (2010)
Cardiac ion channels in health and disease
Ahmad S. Amin et al.
HEART RHYTHM (2010)
Congenital Insensitivity to Pain: Novel SCN9A Missense and In-frame Deletion Mutations
James J. Cox et al.
HUMAN MUTATION (2010)
Cardiac ion channel gene mutations in Greek long QT syndrome patients
C-M Kotta et al.
JOURNAL OF APPLIED GENETICS (2010)
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents
Brian W. Jarecki et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology
Hugues Abriel
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
Cooccupancy of the Outer Vestibule of Voltage-Gated Sodium Channels by μ-Conotoxin KIIIA and Saxitoxin or Tetrodotoxin
Min-Min Zhang et al.
JOURNAL OF NEUROPHYSIOLOGY (2010)
Antillatoxin, a Novel Lipopeptide, Enhances Neurite Outgrowth in Immature Cerebrocortical Neurons through Activation of Voltage-Gated Sodium Channels
S. V. Jabba et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
NaV1.1 channels and epilepsy
William A. Catterall et al.
JOURNAL OF PHYSIOLOGY-LONDON (2010)
Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects
Miriam H. Meisler et al.
JOURNAL OF PHYSIOLOGY-LONDON (2010)
Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders
Massimo Mantegazza et al.
LANCET NEUROLOGY (2010)
Molecular genetics of long QT syndrome
Nilesh J. Bokil et al.
MOLECULAR GENETICS AND METABOLISM (2010)
Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability
Mark Estacion et al.
MOLECULAR PAIN (2010)
Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore
Gregory M. Lipkind et al.
MOLECULAR PHARMACOLOGY (2010)
The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation
Yucheng Xiao et al.
MOLECULAR PHARMACOLOGY (2010)
The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel
Harry A. Fozzard et al.
MARINE DRUGS (2010)
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
Nona Sotoodehnia et al.
NATURE GENETICS (2010)
A-887826 is a structurally novel, potent and voltage-dependent Nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats
Xu-Feng Zhang et al.
NEUROPHARMACOLOGY (2010)
Ranolazine Attenuation of CFA-induced Mechanical Hyperalgesia
Gregory P. Casey et al.
PAIN MEDICINE (2010)
State-dependent modification of voltage-gated sodium channels by pyrethroids
David M. Soderlund
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2010)
Cardiac sodium channelopathies
Ahmad S. Amin et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2010)
Antinociceptive effect of ambroxol in rats with neuropathic spinal cord injury pain
Aldric T. Hama et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2010)
Control of transient, resurgent, and persistent current by open-channel block by Na channel β4 in cultured cerebellar granule neurons
Jason S. Bant et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement
Xiaorui Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Targeting voltage sensors in sodium channels with spider toxins
Frank Bosmans et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2010)
Fast- or Slow-inactivated State Preference of Na+ Channel Inhibitors: A Simulation and Experimental Study
Robert Karoly et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
RECENT ADVANCES IN ADJUNCTIVE THERAPY FOR EPILEPSY: FOCUS ON SODIUM CHANNEL BLOCKERS AS THIRD-GENERATION ANTIEPILEPTIC DRUGS
D. Vohora et al.
DRUGS OF TODAY (2010)
Function and role of voltage-gated sodium channel Na(V)1.7 expressed in aortic smooth muscle cells
Kentaro Meguro et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
A Peripherally Acting Nav1.7 Sodium Channel Blocker Reverses Hyperalgesia and Allodynia on Rat Models of Inflammatory and Neuropathic Pain
Erin McGowan et al.
ANESTHESIA AND ANALGESIA (2009)
A Novel Nav1.7 Mutation Producing Carbamazepine-Responsive Erythromelalgia
Tanya Z. Fischer et al.
ANNALS OF NEUROLOGY (2009)
Ranolazine attenuates behavioral signs of neuropathic pain
Harry J. Gould et al.
BEHAVIOURAL PHARMACOLOGY (2009)
Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides
Yuzhe Du et al.
BIOCHEMICAL JOURNAL (2009)
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers
Pengcheng P. Shao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain
Pengcheng P. Shao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Subtype-selective targeting of voltage-gated sodium channels
Steve England et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria
Alban Pereira et al.
CHEMISTRY & BIOLOGY (2009)
Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Na-v, K(Ca)2.3, and K(v)11.1 Channels
Mads P. G. Korsgaard et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2009)
Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms
Neil Castle et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2009)
Voltage-Gated Sodium Channel Blockers for the Treatment of Chronic Pain
Mark A. Matulenko et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
Recent Advances in the Medicinal Chemistry of Sodium Channel Blockers and their Therapeutic Potential
Valentina Zuliani et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat
Charles H. Large et al.
EPILEPSY RESEARCH (2009)
Myocardial protection by F 15845, a persistent sodium current blocker, in an ischemia-reperfusion model in the pig
Robert Letienne et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
The Genetic Basis of Brugada Syndrome: A Mutation Update
Paula L. Hedley et al.
HUMAN MUTATION (2009)
Structural Determinants of Drugs Acting on the Nav1.8 Channel
Liam E. Browne et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
3-(R)-[3-(2-Methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine Bromhydrate (F 15845) Prevents Ischemia-Induced Heart Remodeling by Reduction of the Intracellular Na+ Overload
Bruno Vie et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Gabapentin selectively reduces persistent sodium current in injured type-A dorsal root ganglion neurons
Rui-Hua Yang et al.
PAIN (2009)
Congenital insensitivity to pain
N. Danziger et al.
REVUE NEUROLOGIQUE (2009)
Imidazopyridines:: A novel class of hNav1.7 channel blockers
Clare London et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The cardiac persistent sodium current: an appealing therapeutic target?
D. A. Saint
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Block of tetrodotoxin-sensitive, NaV1.7 and tetrodotoxin-resistant, NaV1.8, Na+ channels by ranolazine
Sridharan Rajamani et al.
CHANNELS (2008)
Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation
Dawood Darbar et al.
CIRCULATION (2008)
Clinical Impact of Genetic Studies in Lethal Inherited Cardiac Arrhythmias
Wataru Shimizu
CIRCULATION JOURNAL (2008)
Sodium channels and nociception: recent concepts and therapeutic opportunities
Douglas S. Krafte et al.
CURRENT OPINION IN PHARMACOLOGY (2008)
Cardiac sodium channels and inherited electrophysiologic disorders: a pharmacogenetic overview
Jeroen P. P. Smits et al.
EXPERT OPINION ON PHARMACOTHERAPY (2008)
Conotoxin modulation of voltage-gated sodium channels
J. Ekberg et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration
Yucheng Xiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Sodium late current blockers in ischemia reperfusion: Is the bullet magic?
Bruno Le Grand et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders
M. Estacion et al.
JOURNAL OF NEUROSCIENCE (2008)
Differential block of sensory neuronal voltage-gated sodium channels by Lacosamide[(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine
Patrick L. Sheets et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Persistent pain:: the contribution of NaV1.9
Ewan St. John Smith et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9
Johan A. R. Ostman et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
Navigating the channels and beyond: unravelling the genetics of the epilepsies
Ingo Helbig et al.
LANCET NEUROLOGY (2008)
ProTx-II, a Selective Inhibitor of Nav1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors
William A. Schmalhofer et al.
MOLECULAR PHARMACOLOGY (2008)
How membrane proteins sense voltage
Francisco Bezanilla
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat
Shi-Hong Zhang et al.
PAIN (2008)
C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels
Wen Hua Xiao et al.
PAIN (2008)
Tetrodotoxin - A brief history
Toshio Narahashi
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2008)
Two novel sodium channel inhibitors from Heriaeus melloteei spider venom differentially interacting with mammalian channel's isoforms
Bert Billen et al.
TOXICON (2008)
Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels
Yucheng Mao et al.
TOXICON (2008)
State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine
Ging Kuo Wang et al.
MOLECULAR PHARMACOLOGY (2008)
A selective Nav 1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats
Steve McGaraughty et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
The Investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels
Adam C. Errington et al.
MOLECULAR PHARMACOLOGY (2008)
Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7
Brande S. Williams et al.
BIOCHEMISTRY (2007)
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders
Joost P. H. Drenth et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Benzazepinone Nav1.7 blockers:: Potential treatments for neuropathic pain
Scott B. Hoyt et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Double-blind, placebo-con trolled trial of lamotrigine in combination with other medications for neuropathic pain
Marianne Silver et al.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2007)
Sodium channels: Ionic model of slow inactivation and state-dependent drug binding
Denis B. Tikhonov et al.
BIOPHYSICAL JOURNAL (2007)
Discovery of a novel class of benzazepinone Nav1.7 blockers:: Potential treatments for neuropathic pain
Scott B. Hoyt et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Paroxysmal extreme pain disorder (previously familial rectal pain syndrome)
C. R. Fertleman et al.
NEUROLOGY (2007)
Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function
K. Sreeramulu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity
Patrick L. Sheets et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Michael F. Jarvis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Small interfering RNA-mediated selective knockdown of Nav1.8 tetrodotoxin-resistent sodium channel reverses mechanical allodynia in neuropathic rats
X.-W. Dong et al.
NEUROSCIENCE (2007)
Molecular interactions of the gating modifier toxin ProTx-II with Nav1.5 - Implied existence of a novel toxin binding site coupled to activation
Jaime J. Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Insect-selective spider toxins targeting voltage-gated sodium-channels
Graham M. Nicholson
TOXICON (2007)
The insecticidal potential of scorpion β-toxins
Michael Gurevitz et al.
TOXICON (2007)
A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile
Paul W. Lenkowski et al.
NEUROPHARMACOLOGY (2007)
Use of amino acid composition to predict ligand-binding sites
Shinji Soga et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2007)
Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels
Gerardo Corzo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ProTx-1 and ProTx-II: Gating modifiers of voltage-gated sodium channels
Birgit T. Priest et al.
TOXICON (2007)
Voltage-gated ion channels and gating modifier toxins
William A. Catterall et al.
TOXICON (2007)
A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis
Brenda Breuer et al.
CLINICAL THERAPEUTICS (2007)
Lacosamide: A review of preclinical properties
Bettina K. Beyreuther et al.
CNS DRUG REVIEWS (2007)
Sodium channel auxiliary subunits
Tsai-Tien Tseng et al.
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY (2007)
Molecular targets for antiepileptic drug development
Brian S. Meldrum et al.
NEUROTHERAPEUTICS (2007)
Blocking sodium channels to treat neuropathic pain
Birgit T. Priest et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
An SCN9A channelopathy causes congenital inability to experience pain
James J. Cox et al.
NATURE (2006)
SCN9A mutations in paroxysmal extreme pain disorder:: Allelic variants underlie distinct channel defects and phenotypes
Caroline R. Fertleman et al.
NEURON (2006)
Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine
Denis B. Tikhonov et al.
FEBS LETTERS (2006)
μO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
J. Ekberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice
Mohammed A. Nassar et al.
MOLECULAR PAIN (2006)
The role of sodium channels in neuropathic pain
Marc Rogers et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2006)
Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury
Angelika Lampert et al.
EXPERIMENTAL BRAIN RESEARCH (2006)
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy
Frank H. Yu et al.
NATURE NEUROSCIENCE (2006)
Structure and function of the voltage sensor of sodium channels probed by a β-scorpion toxin
Sandrine Cestele et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Structural model reveals key interactions in the assembly of the pregnane X receptor/corepressor complex
CY Wang et al.
MOLECULAR PHARMACOLOGY (2006)
Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential
CJ Huang et al.
NATURE BIOTECHNOLOGY (2006)
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes
F Bosmans et al.
MOLECULAR PHARMACOLOGY (2006)
State-dependent compound inhibition of Nav1.2 sodium channels using the FLIPR Vm dye:: On-target and off-target effects of diverse pharmacological agents
ER Benjamin et al.
JOURNAL OF BIOMOLECULAR SCREENING (2006)
Effects of δ-conotoxins PVIA and SVIE on sodium channels in the amphibian sympathetic nervous system
PJ West et al.
JOURNAL OF NEUROPHYSIOLOGY (2005)
Erythermalgia: molecular basis for an inherited pain syndrome
SG Waxman et al.
TRENDS IN MOLECULAR MEDICINE (2005)
Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue
A Leffler et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2005)
Ambroxol, a Nav 1.8-preferring Na+ channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain
W Gaida et al.
NEUROPHARMACOLOGY (2005)
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels
WA Catterall et al.
PHARMACOLOGICAL REVIEWS (2005)
Sodium channel inactivation: Molecular determinants and modulation
W Ulbricht
PHYSIOLOGICAL REVIEWS (2005)
β-Scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels
M Mantegazza et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Sodium channel activators: Model of binding inside the pore and a possible mechanism of action
DB Tikhonov et al.
FEBS LETTERS (2005)
Sodium channel mutations in epilepsy and other neurological disorders
MH Meisler et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Molecular interaction of δ-conotoxins with voltage-gated sodium channels
E Leipold et al.
FEBS LETTERS (2005)
Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Nav1.9 to sensory transmission and nociceptive behavior
BT Priest et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels
JPH Drenth et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2005)
Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons
TR Cummins et al.
FEBS LETTERS (2005)
A spider toxin that induces a typical effect of scorpion α-toxins but competes with β-toxins on binding to insect sodium channels
G Corzo et al.
BIOCHEMISTRY (2005)
Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding
JG Tan et al.
MOLECULAR PHARMACOLOGY (2005)
Spinal and supraspinal contributions to central sensitization in peripheral neuropathy
R Suzuki et al.
NEUROSIGNALS (2005)
The glycinergic control of spinal pain processing
HU Zeilhofer
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Mechanism of local anesthetic drug action on voltage-gated sodium channels
HA Fozzard et al.
CURRENT PHARMACEUTICAL DESIGN (2005)
Modeling P-loops domain of sodium channel: Homology with potassium channels and interaction with ligands
DB Tikhonov et al.
BIOPHYSICAL JOURNAL (2005)
Potassium, sodium, calcium and glutamate-gated channels: pore architecture and ligand action
BS Zhorov et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Structure-activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel Blockers
DL Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain
MA Nassar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Modulation of voltage-dependent sodium channels by the δ-agonist SNC80 in acutely isolated rat hippocampal neurons
C Remy et al.
NEUROPHARMACOLOGY (2004)
The neurobiology of antiepileptic drugs
MA Rogawski et al.
NATURE REVIEWS NEUROSCIENCE (2004)
Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes
YC Xiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
First chemical synthesis of a Scorpion α-toxin affecting sodium channels:: The Aah I toxin Androctonus australis hector
S M'Barek et al.
JOURNAL OF PEPTIDE SCIENCE (2004)
Molecular changes in neurons in multiple sclerosis:: Altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger
MJ Craner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury
BC Hains et al.
JOURNAL OF NEUROSCIENCE (2004)
Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins:: hainantoxin-III and hainantoxin-IV
XC Xiao et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel
G Corzo et al.
FEBS LETTERS (2003)
Mechanisms of sodium channel inactivation
AL Goldin
CURRENT OPINION IN NEUROBIOLOGY (2003)
Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule
GK Wang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2003)
Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana
Z Liu et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2003)
Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Nav1.4 sodium channel as revealed by improved estimation of toxin sensitivity
H Maejima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins
SY Wang et al.
CELLULAR SIGNALLING (2003)
Inhibition of Na+ current by imipramine and related compounds:: Different binding kinetics as an inactivation stabilizer and as an open channel blocker
YC Yang et al.
MOLECULAR PHARMACOLOGY (2002)
Inhibition of Tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na+ channels by the secretolytic ambroxol
T Weiser et al.
MOLECULAR PHARMACOLOGY (2002)
Erythromelalgia: an endothelial disorder responsive to sodium nitroprusside
MKH Chan et al.
ARCHIVES OF DISEASE IN CHILDHOOD (2002)
Structural determinants for the action of grayanotoxin in D1 S4-S5 and D4 S4-S5 intracellular linkers of sodium channel α-subunits
H Maejima et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons
RC Hogg et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
The batrachotoxin receptor on the voltage-gated sodium channel is guarded by the channel activation gate
HL Li et al.
MOLECULAR PHARMACOLOGY (2002)
Ion-channel assay technologies:: quo vadis?
J Xu et al.
DRUG DISCOVERY TODAY (2001)
Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels
WI Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Neuronal sodium-channel α1-subunit mutations in generalized epilepsy with febrile seizures plus
RH Wallace et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: Evidence for two mechanisms
IM Raman et al.
BIOPHYSICAL JOURNAL (2001)
Sodium channel β subunits:: Anything but auxiliary
LL Isom
NEUROSCIENTIST (2001)
Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na+ channel α subunit
V Yarov-Yarovoy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities
JA Kearney et al.
NEUROSCIENCE (2001)
Slow inactivation in voltage-gated sodium channels - Molecular substrates and contributions to channelopathies
YY Vilin et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2001)
Voltage-gated sodium channels as therapeutic targets
JJ Clare et al.
DRUG DISCOVERY TODAY (2000)
Potent analgesic effects of GDNF in neuropathic pain states
TJ Boucher et al.
SCIENCE (2000)
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels
S Cestèle et al.
BIOCHIMIE (2000)
Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and LqhαIT
HJ Chen et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2000)
Isolation and pharmacological characterisation of δ-atracotoxin-Hv1b, a vertebrate-selective sodium channel toxin
TH Szeto et al.
FEBS LETTERS (2000)
On site of action of grayanotoxin in domain 4 segment 6 of rat skeletal muscle sodium channel
T Kimura et al.
FEBS LETTERS (2000)