期刊
CHEMMEDCHEM
卷 3, 期 7, 页码 1061-1070出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.200800021
关键词
alpha-galactosylceramide; cytokines; epimers; glycolipids; NKT cells
资金
- Cancer Research UK [10601] Funding Source: Medline
alpha-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after alpha-GalCer presentation, antagonize each other's effects, a-GalCer analogues-that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of alpha-Gal-D-Xylo-Cer and two alpha-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.
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