4.6 Article

A Naphthalimide-Based Fluorescence Turn-On Probe for the Detection of Pb2+ in Aqueous Solution and Living Cells

期刊

CHEMISTRY-AN ASIAN JOURNAL
卷 9, 期 12, 页码 3397-3402

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201402946

关键词

fluorescent probes; lead ion; naphthalimide; photoinduced electron transfer; sensors

资金

  1. National Natural Science Foundation of China [21302058]
  2. Research Fund for the Doctoral Program of Higher Education of China [20130076120006]
  3. Shanghai Key Laboratory of Chemical Biology
  4. Shanghai Rising-Star Program [14QB1404800]
  5. Fundamental Research Funds for the Central Universities

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An easily available naphthalimide-based fluorescent probe NPA for Pb2+ detection was successfully developed. NPA exhibited an obvious fluorescence turn-on response toward Pb2+ in aqueous solution and in living cells. Moreover, a series of model compounds were rationally designed and synthesized in order to explore the sensing mechanism and binding mode of NPA with Pb2+.

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