期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 9, 期 8, 页码 1994-2003出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201402061
关键词
bioorthogonality; boronic acids; click reactions; pH-reversibility
资金
- BMBF
- ERC [319130-BioQ]
The interaction of boronic acids with various bifunctional reagents offers great potential for the preparation of responsive supramolecular architectures. Boronic acids react with 1,2-diols yielding cyclic boronate esters that are stable at pH> 7.4 but can be hydrolyzed at pH< 5.0. The phenylboronic acid (PBA)-salicylhydroxamic acid (SHA) system offers ultra-fast reaction kinetics and high binding affinities. This Focus Review summarizes the current advances in exploiting the bioorthogonal interaction of boronic acids to build pH-responsive supramolecular architectures in water.
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