期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 9, 期 10, 页码 2921-2927出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201402399
关键词
bioimaging; dyes; pigments; nanoparticles; pH sensitive; UV sensitive
资金
- Ministry of Trade, Industry, and Energy (MOTIE) [R0001435, 10046506]
- Fusion Research R&D Program from the Korea Research Council for Industrial Science Technology [G02054]
We report a stimuli-responsive fluorescent nanomaterial, based on graphene oxide coupled with a polymer conjugated with photochromic spiropyran (SP) dye and hydrophobic boron dipyrromethane (BODIPY) dye, for application in triggered target multicolor bioimaging. Graphene oxide (GO) was reduced by catechol-conjugated polymers under mildly alkaline conditions, which enabled to formation of functionalized multicolor graphene nanoparticles that can be induced by irradiation with UV light and by changing the pH from acidic to neutral. Investigation of these nanoparticles by using AFM, fluorescence emission, and in vitro cell and in vivo imaging revealed that they show different tunable colors in bioimaging applications and, more specifically, in cancer-cell detection. The stability, biocompatibility, and quenching efficacy of this nanocomposite open a different perspective for cell imaging in different independent colors, sequentially and simultaneously.
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