期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 9, 期 1, 页码 48-57出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201301294
关键词
cancer; chemotherapy; combined therapies; drug delivery; radiotherapy; stimuli response
资金
- National Basic Research Program of China [2013CB834502]
- National Natural Science Foundation of China [21074066]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [21121004]
- Tsinghua University Initiative Scientific Research Program [2012Z02131]
- NSFC-DFG [TRR 61]
Research on anticancer therapies has advanced significantly in recent years. New therapeutic platforms that can further improve the health of patients are still highly demanded. We propose the idea of combining regular chemotherapy with radiation therapy to minimize side effects as well as increase drug-delivery efficiency. In this Focus Review, we seek to provide an overview of recent advances that can combine chemotherapy and radiotherapy. We begin by reviewing the current state of systems that can combine chemotherapy and gamma radiation. Among them, diselenide-containing polymers are highlighted as sensitive drug-delivery vehicles that can disassemble under gamma radiation. Then X-ray responsive materials as promising alternative systems are summarized, including X-ray responsive drug-delivery vehicles, prodrugs that can be activated by X-rays, and radiation-site-targeting systems. Finally, we describe strategies that involve phototherapies.
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