期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 8, 期 10, 页码 2304-2314出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201300630
关键词
bioelectronics; electrochemistry; field-effect transistors; flexible electronics; nanostructures; neural mapping; synthetic biology
资金
- NIH Director's Pioneer Award [5DP1OD003900]
- McKnight Foundation Technological Innovations in Neurosciences Award
- National Security Science and Engineering Faculty Fellow (NSSEFF) award [N00244-09-1-0078]
- National Thousand Talents Plan award from China
- National Basic Research Program of China [2014CB932500]
High spatiotemporal resolution interfaces between electrical sensors and biological systems, from single live cells to tissues, is crucial for many areas, including fundamental biophysical studies as well as medical monitoring and intervention. Herein, we summarize recent progress in the development and application of novel nanoscale devices for intracellular electrical recording of action potentials and the effort of merging electronic and biological systems seamlessly in three dimensions by using macroporous nanoelectronic scaffolds. The uniqueness of these nanoscale devices for minimally invasive, large-scale, high spatial resolution, and three-dimensional neural activity mapping are highlighted.
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