期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 7, 期 10, 页码 2411-2418出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201200467
关键词
alkynes; butyrolactones; carbon dioxide; hydrocarboxylation; nickel
资金
- National Basic Research Program of China [2009CB825300]
- National Natural Science Foundation of China [20732005]
- Project for Basic Research in Natural Science Issued by Shanghai Municipal Committee of Science [08dj1400100]
An efficient nickel(0)-catalyzed highly regio- and stereoselective hydrocarboxylation of homopropargylic alcohols with ZnEt2 in the presence of CO2 (1 atm, balloon) to synthesize a-alkylidene-?-butyrolactones is described. The catalyst is highly active and can be applied for the synthesis of (optically active) mono- or bicyclic a-alkylidene-?-butyrolactones with excellent regio- and stereoselectivity and good functional group tolerance. The potential of the reaction has been demonstrated in the first synthesis of (+/-)-heteroplexisolide E.
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