期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 6, 期 9, 页码 2332-2338出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201100064
关键词
mesoporous; photodynamic therapy; photosensitizers; silica nanoparticles
资金
- 973 program [2010CB226901, 2007CB714506]
- NSFC [20925517]
- STCM of Shanghai [10XD1406000, 09JC1402600]
- Australian Research Council
Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl2 (82.6% in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl2 being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl2 at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti-cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs.
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