期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 6, 期 11, 页码 3059-3065出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201100470
关键词
biaryls; C-H activation; cross-coupling; Grignard reagent; iron
资金
- MEXT [22000008, 23750100]
- Global COE program for Chemistry Innovation
- Japan Society for the Promotion of Science [23.8207]
- Grants-in-Aid for Scientific Research [23750100, 22000008, 11J08207] Funding Source: KAKEN
Direct arylation of the ortho-C-H bond of an aryl pyridine or an aryl imine with an aryl Grignard reagent has been achieved by using an iron-diamine catalyst and a dichloroalkane as an oxidant in a short reaction time (e. g., 5 min) under mild conditions (0 degrees C). The use of an aromatic co-solvent, such as chlorobenzene and benzene, and slow addition of the Grignard reagent are essential for the high efficiency of the reaction. The present arylation reaction has distinct merits over the previously developed reaction that used an arylzinc reagent, such as its reaction rate and atom economy. Selective C-H bond activation occurs in the presence of a leaving group, such as a tosyloxy, chloro, and bromo group. Studies on a stoichiometric reaction and kinetic isotope effects shed light on the reaction intermediate and the C-H bond-activation step.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据