期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 3, 期 11, 页码 1929-1934出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200800213
关键词
lithiation; lithium; N ligands; structure-activity relationships; structure elucidation
资金
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie
alpha-Lithiated tertiary methylamines are important building blocks in all fields of chemistry, such as for the synthesis of new ligand or catalyst systems. However, the access to these compounds is still limited and the reaction mechanism, in general, not fully understood. We present herein X-ray diffraction analyses of organolithium compounds with 1,2,3-trimethyl-1,3,5-triazacyclohexane (1), such as a pre-coordination adduct of tert-butyllithium, [(tBuLi)(3 center dot)C6H15N3], which represents a potential intermediate of the lithiation of the methylene group of this ligand. By means of molecular structures and computational studies, the regioselectivity of this deprotonation reaction can be understood. Furthermore, the tBuLi adduct gives a hint to an alternative deaggregation process of organolithium compounds.
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