期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 3, 期 8-9, 页码 1523-1534出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200800062
关键词
amphidinolides; anti-cancer agents; macrolides; natural products; total synthesis
资金
- MarineBio21
- Ministry of Maritime Affairs and Fisheries, Korea
- Center for Bioactive Molecular Hybrids
- KOSEF
The total synthesis of (-)-amphidinolide E was accomplished by following a synthetic scheme that incorporates the labile C2 stereocenter at a very late stage. The oxolane unit was prepared by beta-alkoxyacrylate radical cyclization. The enyne metathesis reaction was employed for the synthesis of the side chain. ne Kocienski-Julia reaction was used for the union of the two major fragments, and the Kita macrolactonization protocol was used for macrolide synthesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据