期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 3, 期 2, 页码 216-224出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200700360
关键词
asymmetric synthesis; multicomponent reactions; nitrogen heterocycles; organocatalysis; reduction
An easy and simple one-pot approach for the formation of optically active substituted I.,4-dihydropyridines by using asymmetric organocatalysis is presented. The one-pot reaction of alpha,beta-unsaturated aldehydes with beta-diketones or beta-ketoesters and primary amines gives optically active 2,3-substituted 1,4-dihydropyridines in moderate yields and with enantioselectivities up to 95 % ee. It is also demonstrated that the optically active 1,4-dihydropyridines can be used in situ for the direct enantioselective reduction of, for example, alpha-ketoesters with high enantioselectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据