期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 1, 页码 20-25出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201803389
关键词
drug delivery; lipids; liposomes; molecular recognition; self-assembly
资金
- National Science Foundation [DMR-1807689]
- com for Smoke and Haze Cloud Dover Stock Photo-PNG 5
Advancements in the field of liposomal drug carriers have culminated in greatly improved delivery properties. An important aspect of this work entails development of designer liposomes for release of contents triggered by environmental changes. The majority of these systems are driven by chemical reactions in the presence of different stimuli. However, a promising new paradigm instead focuses on molecular recognition events as the impetus for content release. In certain cases, these platforms exploit synthetic lipid switches designed to undergo conformational changes upon binding to target ions or molecules that perturb membrane assembly, thereby triggering cargo release. Examples of this approach reported thus far showcase how rational design of lipid switches can result in dramatic changes in lipid assembly properties. These strategies show great promise for opening up new pathophysiological stimuli that can be harnessed for programmed content release in drug delivery applications.
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