期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 2, 页码 417-430出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201802691
关键词
DNA; G-quadruplexes; molecular recognition; noncovalent interactions; RNA
资金
- JSPS research fellowship
A G-quadruplex is a nucleic acid secondary structure that is adopted by guanine-rich sequences, and is considered to be relevant in various pharmacological and biological contexts. G-Quadruplexes have also attracted great attention in the field of DNA nanotechnology because of their extremely high thermal stability and the availability of many defined structures. To date, a large repertory of DNA/RNA G-quadruplex-interactive ligands has been developed by numerous laboratories. Several relevant reviews have also been published that have helped researchers to grasp the full scope of G-quadruplex research from its outset to the present. This review focuses on the G-quadruplex ligands that allow targeting of specific G-quadruplexes. Moreover, unique ligands, successful methodologies, and future perspectives in relation to specific G-quadruplex recognition are also addressed.
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