期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 67, 页码 17788-17795出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201803902
关键词
anion recognition; halogen bonding; orthosteric regulation; rotaxane; transition metals
资金
- CSC (China Scholarship Council)
- Agency for Science, Technology and Research (A*STAR), Singapore
The ability of natural enzymes to regulate their guest binding affinities and preferences through the use of co-ligands which alter the features of the binding site is fundamental to biological homeostatic control. Herein, the rarely exploited orthosteric control of guest binding is demonstrated using neutral halogen bonding [2]rotaxanes, in which a chemical stimulus (acid) interacting with the interlocked host binding site switches the host's native guest preference from metal cations to anions. When neutral, the rotaxanes exhibit pronounced transition metal cation affinity and comparatively weak anion binding properties. However, the addition of acid attenuates the rotaxanes' ability to coordinate cations, while concurrently enabling strong binding of halides through charge assisted halogen bonding and hydrogen bonding interactions in competitive aqueous solvent media. The appendage of a fluorescent anthracene reporter group to the rotaxane framework also enables diagnostic sensory responses to cation/anion binding.
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