期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 22, 页码 6786-6794出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201402193
关键词
aggregation; cations; ion exchange; metallacarboranes; self-assembly
资金
- MICINN [CTQ2010-16237]
- CSIC [I3P]
- MICINN (FPU)
- Generalitat de Catalunya [2009/SGR/00279]
- Grant Agency of the Academy of Sciences of the Czech Republic [IAAX00320901]
- Grant Agency of the Czech Republic [P208/12/P236]
- Ministry of Education of the Czech Republic [MSM 0021620857]
The anion [3,3-Co(C2B9H11)(2)](-) ([COSAN](-)) produces aggregates in water. These aggregates are interpreted to be the result of CHHB interactions. It is possible to generate aggregates even after the incorporation of additional functional groups into the [COSAN](-) units. The approach is to join two [COSAN](-) anions by a linker that can adapt itself to act as a crown ether. The linker has been chosen to have six oxygen atoms, which is the ideal number for K+ selectivity in crown ethers. The linker binds the alkaline metal ions with different affinities; thus showing a distinct degree of selectivity. The highest affinity is shown towards K+ from a mixture containing Li+, Na+, K+, Rb+ and Cs+; this can be indicative of pseudo-crown ether performance of the dumbbell. One interesting possibility is that the [COSAN](-) anions at the two ends of the linker can act as a hook-and-loop fastener to close the ring. This facet is intriguing and deserves further consideration for possible applications. The distinct affinity towards alkaline metal ions is corroborated by solubility studies and isothermal calorimetry thermograms. Furthermore, cryoTEM micrographs, along with light scattering results, reveal the existence of small self-assemblies and compact nanostructures ranging from spheres to single-/multi-layer vesicles in aqueous solutions. The studies reported herein show that these dumbbells can have different appearances, either as molecules or aggregates, in water or lipophilic phases; this offers a distinct model as drug carriers.
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