期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 4, 页码 1468-1473出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405672
关键词
copper; cyclization; radical reactions; tandem reactions; trifluoromethylation
资金
- National Science Foundation [NSF21072080, 21302076, 21472074]
- 111 Project
- Program for Chang-jiang Scholars and Innovative Research Team in University [IRT1138]
A copper-catalyzed difunctionalizing trifluoromethylation of activated alkynes with the cheap reagent sodium trifluoromethanesulfinate (NaSO2CF3 or Langlois' reagent) has been developed incorporating a tandem cyclization/dearomatization process. This strategy affords a straightforward route to synthesis of 3-(trifluoromethyl)-spiro[4.5]trienones, and presents an example of difunctionalization of alkynes for simultaneous formation of two carbon-carbon single bonds and one carbon-oxygen double bond.
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