期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 4, 页码 1444-1448出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405888
关键词
alpha-hydroxy carboxylamides; hypervalent compounds; imides; iodine; rearrangements
资金
- Fonds der Chemischen Industrie (Liebig fellowship)
- Emmy-Noether program of the DFG [GU 1134/3-1]
A tertiary hydroxy group a to a carboxyl moiety comprises a key structural motif in many bioactive substances. With the herein presented metal-free rearrangement of imides triggered by hypervalent lambda(3)-iodane, an easy and selective way to gain access to such a compound class, namely alpha,alpha-disubstituted-alpha-hydroxy carboxylamides, was established. Their additional methylene bromide side chain constitutes a useful handle for rapid diversification, as demonstrated by a series of further functionalizations. Moreover, the in situ formation of an iodine(III) species under the reaction conditions was proven. Our findings clearly corroborate that hypervalent lambda(3)-benziodoxolones are involved in these organocatalytic reactions.
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