期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 40, 页码 12740-12744出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404078
关键词
amino alcohols; aminooxygenation; cyclization; electrochemical oxidation; radicals
资金
- Xiamen University
- National Natural Science Foundation of China [21225523]
An electrochemical approach to the intramolecular aminooxygenation of unactivated alkenes has been developed. This process is based on the addition of nitrogen-centered radicals, generated through electrochemical oxidation, to alkenes followed by trapping of the cyclized radical intermediate with 2,2,6,6-tetramethylpiperidine-Noxyl radical (TEMPO). Difunctionalization of a variety of alkenes with easily available carbamates/amides and TEMPO affords aminooxygenation products in high yields and with excellent trans selectivity for cyclic systems (d.r. up to > 20:1). The approach provides a much-needed complementary route to existing cis-selective methods.
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