期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 28, 页码 8599-8602出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201403454
关键词
alkyne; C-H activation; enyne; phenol; rhodium
资金
- ERC
- EPSRC
- GlaxoSmithKline
- University of Nottingham
- EPSRC [EP/I004769/2, EP/I004769/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I004769/2, EP/I004769/1] Funding Source: researchfish
The dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes proceeds with high yields and regioselectivities under Rh-III catalysis. These reactions are successful using Cu(OAc)(2) or air as the stoichiometric oxidant, and provide spirocyclic enones, the basic ring system of which appears in several natural products. Application of this process to the preparation of a highly functionalized tetracycle is also demonstrated.
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