期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 46, 页码 14951-14954出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404757
关键词
DNA origami; DNA structures; gold nanoparticles; photocontrol; strand displacement
资金
- Core Research for Evolutional Science and Technology (CREST) of JST
- JSPS KAKENHI [24310097, 24104002, 25253004, 26620133]
- Mitsubishi Foundation
- Asahi Glass Foundation
- Grants-in-Aid for Scientific Research [24104002, 13J01399, 26620133, 25253004] Funding Source: KAKEN
A photofunctionalized square bipyramidal DNA nanocapsule (NC) was designed and prepared for the creation of a nanomaterial carrier. Photocontrollable open/close system and toehold system were introduced into the NC for the inclusion and release of a gold nanoparticle (AuNP) by photoirradiation and strand displacement. The reversible open and closed states were examined by gel electrophoresis and atomic force microscopy (AFM), and the open behavior was directly observed by high-speed AFM. The encapsulation of the DNA-modified AuNP within the NC was carried out by hybridization of a specific DNA strand (capture strand), and the release of the AuNP was examined by addition of toehold-containing complementary DNA strand (release strand). The release of the AuNP from the NC was achieved by the opening of the NC and subsequent strand displacement.
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