期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 47, 页码 15339-15343出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405296
关键词
amino acids; catalysis; C-C bond formation; nickel; reductive cross-coupling
资金
- 863 Program of the Ministry of Science and Technology [2012AA02A700]
- National Basic Research Program of China (973 program) [2013CB932800]
- NSFC [21472181, 91313301, 21221062]
- SRFDP [20133402120034]
A novel method for the synthesis of non-natural L- and D-amino acids by a Ni-catalyzed reductive cross-coupling reaction is described. This strategy enables the racemization-free cross-coupling of serine/homoserine-derived iodides with aryl/acyl/alkyl halides. It provides convenient access to varieties of enantiopure and functionalized amino acids, which are important building blocks in bioactive compounds and pharmaceuticals.
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