期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 37, 页码 11616-11628出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201402537
关键词
carbohydrates; drug design; enzymes; inhibitors
During the last decades, tremendous chemical efforts have been dedicated to design monovalent inhibitors of carbohydrate-processing enzymes, with comparatively few rewards in terms of marketed drugs. Recently, an alter-native to the traditional lock and key approach has emerged. Multivalency, a widely used strategy for lectin inhibition, has been successfully applied to specific glycosidases and glycosyltransferases.
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