期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 24, 页码 7249-7253出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201403003
关键词
aggregation; deoxyribonucleosides; near-IR imaging; squaraine dyes; viscosity sensors
资金
- National Science Foundation [CHE-0832622]
- US National Academy of Sciences [PGA-P210877]
Deoxyribonucleoside-modified squaraines were synthesized by Sonogashira coupling reactions using an unsymmetrical, terminal alkynylated benzothiazolium squaraine dye. These non-natural nucleosides exhibited fluorescent 'turn-on' properties in viscous conditions with an enhancement of > 300-fold. The viscosity-dependent fluorescence enhancement was attributed to a combination of hampering both molecular aggregation and intramolecular bond rotation of the squaraine probe. Fluorescence microscopy allowed visualization of highly viscous regions during various stages of cellular mitosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据