期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 1, 页码 101-105出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404520
关键词
anti-cancer prodrugs; high drug loading; nanomedicines; self-assembly
资金
- National Science Foundation [CHE-1412295]
- Boston University Flow Cytometry Core Facility
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1057884, 1412295] Funding Source: National Science Foundation
20-(S)-Camptothecin (CPT)-conjugated dipeptides are reported that preassemble into nanotubes with diameters ranging from 80-120 nm. These nanoassemblies maintain a high (similar to 47%) drug loading and exhibit greater drug stability (i.e., resistance to lactone hydrolysis), and consequently greater efficacy against several human cancer cells (HT-29, A549, H460, and H23) in vitro compared with the clinically used prodrug irinotecan. A key and defining feature of this system is the use of the CPT-conjugated dipeptide as both the drug and precursor to the nanostructured carrier, which simplifies the overall fabrication process.
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