期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 2, 页码 554-558出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405420
关键词
alkynes; asymmetric catalysis; azides; click chemistry; copper
资金
- National Natural Science Foundation of China [21173064, 21472031]
- Zhejiang Provincial Natural Science Foundation of China [LR14B030001]
A copper catalyst system derived from TaoPhos and CuF2 was used successfully for catalytic asymmetric Huisgen [3+2] cycloaddition of azides and alkynes to give optically pure products containing succinimide- and triazole-substituted quaternary carbon stereogenic centers. The desired products were obtained in good yields (60-80%) and 85:15 to >99:1 enantiomeric ratio (e.r.) in this click cycloaddition reaction.
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