期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 4, 页码 1458-1462出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405847
关键词
diamines; diastereoselectivity; ligand design; linear ketones; site selectivity
资金
- NSFC [21432003, 81473095, 21202071]
- National S&T Major Project of China [2012ZX09504001-003]
The successful application of imidazole-modified ketones in asymmetric anti-selective Michael reactions with trans-beta-nitroalkenes is presented by employing a newly developed 3-bromothiophene-modified chiral diamine ligand. The corresponding conjugate adduct was submitted to further transformations with Grignard reagents to solve the problem of a-site selectivity of simple linear ketones. Additionally, the syn-selective product was obtained by treating the anti-selective adduct with a simple base. In this way, the site-specific products for both diastereomers in the asymmetric conjugate addition of simple ketones to nitroalkenes can be obtained.
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