Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles

The combination of cinchona-alkaloid-derived primary amine and Au-I-phosphine catalysts allowed the selective CH functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities.