Palladium( II)-Catalyzed ortho-C-H Arylation/Alkylation of N-Benzoyl α-Amino Ester Derivatives

The palladium-catalyzed arylation/alkylation of ortho-CH bonds in N-benzoyl -amino ester derivatives is described. In such a system both the NH-amido and the CO2R groups in the -amino ester moieties play a role in successful CH activation/CC bond formation using iodoaryl coupling partners. A wide variety of functional groups and electron-rich/deficient iodoarenes are tolerated. The yields obtained range from 20 to 95%.