期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 35, 页码 10900-10904出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201403232
关键词
DNA; drug delivery; fluorescence; mesoporous materials; nanotechnology; zeolites
资金
- Helmholtz Virtual Institute Nano-Tracking [VH-VI-421]
- ERC [2009-247365]
- French Embassy in Italy [778588G]
- French government [778588G]
- Fondation CIRFC (Universite de Strasbourg)
- Region Alsace
- Communaute Urbaine de Strasbourg
- Departement du Bas-Rhin
- Ministere de l'Enseignement Superieur de la Recherche (MESR)
The design and synthesis of multifunctional nanomaterials could lead to applications relevant for biomedicine. Manufacturing porous particles to make them able to carry bioactive molecules into living cells represents a substantial goal towards the development of powerful tools for nanomedicine. This work describes a first example of using zeolite-L crystals as multifunctional nanocontainers to simultaneously deliver DNA oligonucleotides and organic molecules into living cells. Multifunctional zeolite-L was prepared by filling the pore system with guest molecules, whilst DNA was adsorbed electrostatically on their surface. The release kinetics of DNA and of the guest molecules into living cells was studied to prove the multiple-drug-delivery ability of the system. The localization of all the components in different cellular compartments was followed. The presented system may be a prototype for the development of novel nanoparticles for drug delivery and gene therapy.
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