期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 17, 页码 4911-4915出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201304835
关键词
asymmetric catalysis; cyanation; magnesium; synthetic methods; unsaturated ketones
资金
- National Natural Science Foundation of China [91213302, 21272102]
- Key National S&T Program Major New Drug Development of the Ministry of Science and Technology of China [2012ZX09504001-003]
- Program for Changjiang Scholars and Innovative Research Team in University [PCSIRT: IRT1137]
Asymmetric cyanation of trimethylsilyl cyanide (TMSCN) with ,-unsaturated amides and ketones, respectively, catalyzed by bifunctional mononuclear 1,1-bi-2-naphthol (BINOL)-Mg and binuclear bis(prophenol)-Mg catalysts was realized. A series of synthetically important 1,4-cyano products were obtained with good to high enantioselectivities (up to 97%ee).
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