期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 26, 页码 8378-8386出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201301348
关键词
cage compounds; drug delivery; metallacages; photodynamic therapy; ruthenium
资金
- Swiss National Science Foundation
- Johnson Matthey Technology Centre
Skin photosensitivity remains one of the main limitations in photodynamic therapy. In this Concept article a strategy to overcome this limitation is described, in which the photosensitizer is hidden inside the hydrophobic cavity of a water-soluble organometallic cage. The metallacage not only protects the photosensitizer from light, it also facilitates its delivery to cancer cells.
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