4.6 Article

Transporting and Shielding Photosensitisers by Using Water-Soluble Organometallic Cages: A New Strategy in Drug Delivery and Photodynamic Therapy

期刊

CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 26, 页码 8378-8386

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201301348

关键词

cage compounds; drug delivery; metallacages; photodynamic therapy; ruthenium

资金

  1. Swiss National Science Foundation
  2. Johnson Matthey Technology Centre

向作者/读者索取更多资源

Skin photosensitivity remains one of the main limitations in photodynamic therapy. In this Concept article a strategy to overcome this limitation is described, in which the photosensitizer is hidden inside the hydrophobic cavity of a water-soluble organometallic cage. The metallacage not only protects the photosensitizer from light, it also facilitates its delivery to cancer cells.

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