期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 21, 页码 6630-6640出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201300339
关键词
bioimaging; carbohydrates; click chemistry; hybrid materials; silsesquioxanes
资金
- Spanish Ministerio de Ciencia e Innovacion [MAT2010-20646-C04-01, MAT2010-20646-C04-03]
- European Social Fund
- Comunidad de Madrid [S2009/PPQ-1634]
- Fondo de Investigacion Sanitaria [FIS PI11/929]
- Obra Social Cajastur-IUOPA
- Ministerio de Ciencia e Innovacion
- CSIC
A general procedure for the assembly of hetero-bifunctional cubic silsesquioxanes with diverse functionality and a perfectly controlled distribution of functional groups on the inorganic framework has been developed. The method is based on a two-step sequence of mono- and hepta-functionalization through the ligand-accelerated copper(I)-catalyzed azidealkyne cycloaddition of a readily available octaazido cubic silsesquioxane. The stoichiometry of the reactants and the law of binomial distribution essentially determine the selectivity of the key monofunctionalization reaction when a copper catalyst with strong donor ligands is used. The methodology has been applied to the preparation of a set of bifunctional nano-building-blocks with orthogonal reactivity for the controlled assembly of precisely defined hybrid nanomaterials and a fluorescent multivalent probe for application in targeted cell-imaging. The inorganic cage provides an improved photostability to the covalently attached dye as well as a convenient framework for the 3D multivalent display of the pendant epitopes. Thus, fluorescent bioprobes based on well-defined cubic silsesquioxanes offer interesting advantages over more conventional fully organic analogues and ill-defined hybrid nanoparticles and promise to become powerful tools for the study of cell biology and for biomedical applications.
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