期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 8, 页码 2839-2847出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202948
关键词
gold; iron; nanoparticles; magnetic properties; multidrug-resistant bacteria
资金
- NSF-PREM [DMR-0611539, DMR-0934218]
- NSF-RISE [HRD-1137763]
- Direct For Education and Human Resources
- Division Of Human Resource Development [1137763] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [934218] Funding Source: National Science Foundation
Over the last few years, one of the most important and complex problems facing our society is treating infectious diseases caused by multidrug-resistant bacteria (MDRB), by using current market-existing antibiotics. Driven by this need, we report for the first time the development of the multifunctional popcorn-shaped iron magnetic coregold plasmonic shell nanotechnology-driven approach for targeted magnetic separation and enrichment, label-free surface-enhanced Raman spectroscopy (SERS) detection, and the selective photothermal destruction of MDR Salmonella DT104. Due to the presence of the lightning-rod effect, the coreshell popcorn-shaped gold-nanoparticle tips provided a huge field of SERS enhancement. The experimental data show that the M3038 antibody-conjugated nanoparticles can be used for targeted separation and SERS imaging of MDR Salmonella DT104. A targeted photothermal-lysis experiment, by using 670nm light at 1.5Wcm2 for 10min, results in selective and irreparable cellular-damage to MDR Salmonella. We discuss the possible mechanism and operating principle for the targeted separation, label-free SERS imaging, and photothermal destruction of MDRB by using the popcorn-shaped magnetic/plasmonic nanotechnology.
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