期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 5, 页码 1778-1783出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202038
关键词
cancer therapy; drug delivery; enzymes; mesoporous materials; nanoparticles
资金
- National Basic Research Program of China [2011CB936004, 2012CB720602]
- National Natural Science Foundation of China [20831003, 90813001, 20833006, 90913007, 21072182]
In this paper, we present a facile strategy to synthesize hyaluronic acid (HA) conjugated mesoporous silica nanoparticles (MSP) for targeted enzyme responsive drug delivery, in which the anchored HA polysaccharides not only act as capping agents but also as targeting ligands without the need of additional modification. The nanoconjugates possess many attractive features including chemical simplicity, high colloidal stability, good biocompatibility, cell-targeting ability, and precise cargo release, making them promising agents for biomedical applications. As a proof-of-concept demonstration, the nanoconjugates are shown to release cargoes from the interior pores of MSPs upon HA degradation in response to hyaluronidase-1 (Hyal-1). Moreover, after receptor-mediated endocytosis into cancer cells, the anchored HA was degraded into small fragments, facilitating the release of drugs to kill the cancer cells. Overall, we envision that this system might open the door to a new generation of carrier system for site-selective, controlled-release delivery of anticancer drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据