期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 38, 页码 12800-12805出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201302328
关键词
copper; fluorine; radical cation; synthetic methods; trifluoromethylation
资金
- American Chemical Society Petroleum Research Fund [52073-DNI1]
- University of Kansas Office of the Provost, Department of Medicinal Chemistry
- [2302264]
The conversion of an alcohol-based functional group, into a trifluoromethyl analogue is a desirable transformation. However, few methods are capable of converting O-based electrophiles into trifluoromethanes. The copper-mediated trifluoromethylation of benzylic xanthates using Umemoto's reagent as the source of CF3 to form CCF3 bonds is described. The method is compatible with an array of benzylic xanthates bearing useful functional groups. A preliminary mechanistic investigation suggests that the CCF3 bond forms by reaction of the substrate with in situ generated CuCF3 and CuOTf. Further evidence suggests that the reaction could proceed via a radical cation intermediate.
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