期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 37, 页码 12547-12552出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201300593
关键词
copper; DNA; donor-acceptor systems; electron transfer; nucleosides
资金
- DFG [SFB/TRR 88]
- Deutsche Forschungsgemeinschaft [DFG Wa 1386/12-2]
- University of Regensburg
- Karlsruhe Institute of Technology
- ARC [FT120100421]
A new C-nucleoside structurally based on the hydroxyquinoline ligand was synthesized that is able to form stable pairs in DNA in both the absence and the presence of metal ions. The interactions between the metal centers in adjacent Cu-II-mediated base pairs in DNA were probed by electron paramagnetic resonance (EPR) spectroscopy. The metal-metal distance falls into the range of previously reported values. Fluorescence studies with a donor-DNA-acceptor system indicate that photoinduced charge-transfer processes across these metal-ion-mediated base pairs in DNA occur more efficiently than over natural base pairs.
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