Novel Ferrocenyl Linked Pyrazoline Analogs as Potent Antiamoebic Agents

Some novel ferrocenyl linked pyrazoline analogs were synthesized, well characterized, and evaluated for in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. Most of the compounds exhibited higher antiamoebic activity with the IC50 value in the range of 0.12-1.20M, than the reference drug metronidazole, (IC50 value of 1.78M). Compound 9 showed the most promising antiamoebic activity (IC50=0.12M), concluding that these compounds hold immense potential to be employed as new antiamoebic agents. Also, being novel, they can be a solution to the increasing resistance that has posed a major problem globally.