期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 24, 页码 7982-7988出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201300019
关键词
gold; heterocycles; homogeneous catalysis; multicomponent reactions; oxazoles
资金
- Lund University Faculty of Science
- Royal Physiographical Society in Lund
- Swedish Research Council
Multicomponent reactions are attractive for assembling functionalized heterocyclic compounds. To this end, an efficient gold-catalyzed three-component domino reaction to form oxazoles directly from imines, alkynes, and acid chlorides is presented. The reaction proceeds in a single synthetic step by using a gold(III)-N,N-ethylenebis(salicylimine) (salen) catalyst to give trisubstituted oxazoles in up to 96% yield. The substrate scope, a mechanistic study exploring the role of the gold catalyst, and the synthetic applications of the oxazole products are discussed.
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