期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 12, 页码 4030-4035出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202666
关键词
alcohols; amines; domino reactions; enzymes; oxidation
资金
- Evonik Industries AG
- German Federal Ministry of Education and Research (BMBF: project BioxAmine)
- European Union [245144]
- Federal Ministry of Economy, Family and Youth (BMWFJ)
- Federal Ministry of Traffic, Innovation and Technology (bmvit)
- Styrian Business Promotion Agency (SFG)
- Standortagentur Tirol and ZIT
- Technology Agency of the City of Vienna, through the COMET
- Austrian Science Fund (FWF) [W 901] Funding Source: researchfish
Various artificial network designs that involve biocatalysts were tested for the asymmetric amination of sec-alcohols to the corresponding -chiral primary amines. The artificial systems tested involved three to five redox enzymes and were exemplary of a range of different sec-alcohol substrates. Alcohols were oxidised to the corresponding ketone by an alcohol dehydrogenase. The ketones were subsequently aminated by employing a -transaminase. Of special interest were redox-neutral designs in which the hydride abstracted in the oxidation step was reused in the amination step of the cascade. Under optimised conditions up to 91% conversion of an alcohol to the amine was achieved.
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