期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 1, 页码 83-86出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201303385
关键词
asymmetric synthesis; carboxylic acids; cyclisation; fluorination; lactones
资金
- Alexander von Humboldt Foundation
Catalytic fluorolactonisations of aromatic carboxylic acids have been developed. The reactions proceed under mild conditions using the commercially available reagent Selectfluor. A weak phase transfer of the reagent mediated by Na2CO3 allows the reaction to be conducted in non-polar solvents. Furthermore, by the use of a catalytic amount of (DHQ)(2)PHAL (hydroquinine 1,4-phthalazinediyl diether), the first asymmetric fluorolactonisation has been achieved. The corresponding isobenzofuran core can be found in many biologically active molecules.
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