期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 18, 期 49, 页码 15676-15682出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202433
关键词
cancer; drug delivery; magnetic properties; pH response; poly(acrylic acid)
资金
- National Basic Research Program of China [2010CB327704]
- National High Technology Program of China [2011AA03A407]
- National Natural Science Foundation of China [NSFC 51172228, 21101149, 51172227, 20921002]
Monodisperse poly(acrylic acid)-modified Fe3O4 (PAA@Fe3O4) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated. The PAA polymer was encapsulated into the inner cavity of Fe3O4 hollow spheres by a vacuum-casting route and photo-initiated polymerization. TEM images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. The Fe3O4 spheres, after modification with the PAA polymer, still possess enough space to hold guest molecules. We selected doxorubicin (DOX) as a model drug to investigate the drug loading and release behavior of as-prepared composites. The release of DOX molecules was strongly dependent on the pH value due to the unique property of PAA. The HeLa cell-uptake process of DOX-loaded PAA@Fe3O4 was observed by confocal laser scanning microscopy (CLSM). After being incubated with HeLa cells under magnet magnetically guided conditions, the cytotoxtic effects of DOX-loaded PAA@Fe3O4 increased. These results indicate that pH-responsive magnetic PAA@Fe3O4 spheres have the potential to be used as anticancer drug carriers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据