期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 18, 期 8, 页码 2342-2348出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201103479
关键词
configuration determination; isotopic labeling; mass spectrometry; peptides; structure elucidation
资金
- Deutsche Forschungsgemeinschaft (DFG)
- European Community's Seventh Framework Programme [FP7/2007-2013, 223328]
- Bundesministerium fur Bildung und Forschung (BMBF)
- Frankfurt Initiative for Microbial Sciences (FIMS)
Structure elucidation of natural products including the absolute configuration is a complex task that involves different analytical methods like mass spectrometry, NMR spectroscopy, and chemical derivation, which are usually performed after the isolation of the compound of interest. Here, a combination of stable isotope labeling of Photorhabdus and Xenorhabdus strains and their transaminase mutants followed by detailed MS analysis enabled the structure elucidation of novel cyclopeptides named GameXPeptides including their absolute configuration in crude extracts without their actual isolation.
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