期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 18, 期 30, 页码 9276-9280出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201200367
关键词
enantioselectivity; ketimines; organocatalysis; reaction mechanisms
资金
- A-Step from the Japan Science and Technology Agency (JST) [AS232Z00124G]
- Toyoaki Foundation
- Grants-in-Aid for Scientific Research [11J06270] Funding Source: KAKEN
The organocatalytic enantioselective decarboxylative addition of malonic acid half thioesters to ketimines derived from isatins by using N-heteroarenesulfonyl cinchona alkaloid amides afforded products with high enantioselectivity. The products could be converted into optically active AG-041R. X-ray crystallographic analysis revealed that the hydrogen bonding between the sulfonimide proton and the 8-quinolyl nitrogen atom plays an important role in exerting the enantioselectivity of the reaction.
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