期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 18, 期 31, 页码 9601-9611出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201103604
关键词
indium; indoles; isatogens; natural products; total synthesis
资金
- NCL-IGIB Joint Research Initiative Program [CSIR-NWP-0013]
- CSIR (New Delhi)
A strategy directed towards the total synthesis of isatisine A that involves several late-stage metal-catalyzed transformations that address the key carboncarbon and carbonheteroatom bond formations has been developed. As a part of this strategy, methods for the addition of indoles to isatogens that lead selectively to either 2,2-disubstituted N-hydroxyindolin-3-one or 2,2-disubstituted indolin-3-one compounds have been developed by employing InCl3 as a catalyst or as the reagent. The present methods provide the first examples of the additions of indoles to the isatogen nucleus. To demonstrate its viability, the synthesis of 13-deoxy-isatisine A has been completed in ten steps from a known and easily available lactone.
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