Synthesis and Antimicrobial Activity of Some Novel Hydrazide, Pyrazole, Triazine, Isoxazole, and Pyrimidine Derivatives

In continuation of our efforts to find a new class of antimicrobial agents, a series of pyrazole, 1,2,4-triazine, isoxazole, pyrimidine, and other related products containing a hydrazide moiety were prepared via the reaction of 2-cyano-N-((2-methoxynaphthalen-1-yl)methylene) acetohydrazide (1) with appropriate chemical reagents. These compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration against most of test organisms was performed. Among the tested compounds 4, 5, 6, and 16 displayed excellent antimicrobial activity. All the synthesized products were confirmed by elemental analysis, IR, H-1-NMR, C-13-NMR, and mass spectral data.